经皮穿刺冠脉支架成形术(PTCA)是一种新型的冠心病介入疗法，冠状动脉支架作为支架植入术的核心器件，具有广阔的应用市场。本文研究目的是基于血管支架设计原则，研发制造出新型结构的冠状动脉支架，并对冠脉支架结构分析与设计及其加工工艺做了系统研究。主要包括： 利用三维实体建模软件Pro/E与有限元分析软件ANSYS建立了冠状动脉支架的有限元仿真模型，结合支架的不同结构参数，对支架的膨胀性能进行了模拟分析，考察支架不同结构设计对支架膨胀行为的影响，提出了支架结构一般性设计方法，并在此基础上设计了一种新型结构的冠状动脉支架。 系统地研究了冠脉支架激光精细雕刻技术并找出影响切口质量的因素，编制并优化精细雕刻程序，并实际应用，确定激光切割工艺参数：波长1064nm，光斑直径0.02-0.03㎜，脉宽12-15us，脉冲频率1000-1200Hz，平均功率15W，脉冲能量10-15mJ，辅助气体O₂压力为0.2-0.4Mpa；喷嘴与工件表面距离L=0.7㎜；建立了激光切割过程温度场的数学模型；由阿贝-赫梅特判据判定激光切割系统存在周期性系统误差；实现冠状动脉支架激光精细切割。 设计并制造出适合激光切割后冠脉支架热处理的高真空热处理试验设备，并实验优化出316L不锈钢冠脉支架的真空热处理工艺参数：真空度3×10⁻³Pa～5×10⁻³Pa，热处理温度1020～1040℃，保温时间30s，氩气冷却，流量10mL/min。 与吉林大学第二临床医院联合开展冠脉支架动物试验，试验结果表明了所设计、制造的冠脉支架是可行的。 关键词：冠状动脉支架，有限元，激光切割，高真空热处理

 Percutaneous Transluminal Coronary Angioplasty (PTCA) is a new-style interventional therapeutic procedure to treat occlusive vascular disease like coronary heart disease. The coronary stent as a main device used in implantation of vascular stent has extensive applied market. In this thesis, based on the design philosophy of vascular stent we investigate and fabricate late-model coronary stent. In addition, we also explore the coronary stent structure and processing. The details are as follows: Three-dimensional (3D) finite element emulational models of coronary stents were constructed by Pro/Engineering and ANSYS. The expansion behaviors of the different stents were calculated to investigate the influence of different design of stent. A new structure stent was designed based on the method which has been put forward. Systematically analyze the factors affecting laser cutting notch. Program Laser cutting and practical application. Laser cutting processing parameter were: wavelength 1064nm, spot diameter 0.02-0.03㎜, pulse width 12-15us, pulse frequency 1000-1200Hz, average power 10-15mJ, supplementary gas O₂ pressure 0.2-0.4 Mpa, range between muzzle and workpiece is 0.7㎜; Establish mathematic model of laser cutting temperature field and Predicate the periodic systematic error based on Abbe-Halmiton criterion; Put coronary stent laser fine cutting into realization in the end. Construct the high vacuum heat treatment experimental device fit for coronary stent heat treating after laser cutting. Moreover investigate influence factors related vacuum heat treatment and determine the processing parameters that are dynamic vacuum 3×10⁻³Pa～5×10⁻³Pa, argon shield, velocity of flow 10 mL/min, heat treatment temperature 1020～1040 ℃, holding time 30s, furnace cooling. Animal experiment result combination with the Cardiology Department of the Second Hospital of Jilin University is feasible. Key words: coronary stent, finite element method, laser cutting, high vacuum heat treatment